HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.

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Bibliographic Details
Main Authors:	Alessandra Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva, Nico Mitro, Gaia Cermenati, Federica Gilardi, Béatrice Desvergne, Annapaola Andolfo, Cinzia Magagnotti, Donatella Caruso, Emma De Fabiani, Scott W. Hiebert, Maurizio Crestani
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/e79e6f94830242d2a35e5f6ab7dac919
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spelling	oai:doaj.org-article:e79e6f94830242d2a35e5f6ab7dac9192021-12-02T13:57:33ZHDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning10.1038/s41467-017-00182-72041-1723https://doaj.org/article/e79e6f94830242d2a35e5f6ab7dac9192017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00182-7https://doaj.org/toc/2041-1723Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.Alessandra FerrariRaffaella LongoErika FiorinoRui SilvaNico MitroGaia CermenatiFederica GilardiBéatrice DesvergneAnnapaola AndolfoCinzia MagagnottiDonatella CarusoEmma De FabianiScott W. HiebertMaurizio CrestaniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandra Ferrari Raffaella Longo Erika Fiorino Rui Silva Nico Mitro Gaia Cermenati Federica Gilardi Béatrice Desvergne Annapaola Andolfo Cinzia Magagnotti Donatella Caruso Emma De Fabiani Scott W. Hiebert Maurizio Crestani HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
description	Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.
format	article
author	Alessandra Ferrari Raffaella Longo Erika Fiorino Rui Silva Nico Mitro Gaia Cermenati Federica Gilardi Béatrice Desvergne Annapaola Andolfo Cinzia Magagnotti Donatella Caruso Emma De Fabiani Scott W. Hiebert Maurizio Crestani
author_facet	Alessandra Ferrari Raffaella Longo Erika Fiorino Rui Silva Nico Mitro Gaia Cermenati Federica Gilardi Béatrice Desvergne Annapaola Andolfo Cinzia Magagnotti Donatella Caruso Emma De Fabiani Scott W. Hiebert Maurizio Crestani
author_sort	Alessandra Ferrari
title	HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
title_short	HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
title_full	HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
title_fullStr	HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
title_full_unstemmed	HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
title_sort	hdac3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e79e6f94830242d2a35e5f6ab7dac919
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HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

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