HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.
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Nature Portfolio
2017
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oai:doaj.org-article:e79e6f94830242d2a35e5f6ab7dac9192021-12-02T13:57:33ZHDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning10.1038/s41467-017-00182-72041-1723https://doaj.org/article/e79e6f94830242d2a35e5f6ab7dac9192017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00182-7https://doaj.org/toc/2041-1723Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.Alessandra FerrariRaffaella LongoErika FiorinoRui SilvaNico MitroGaia CermenatiFederica GilardiBéatrice DesvergneAnnapaola AndolfoCinzia MagagnottiDonatella CarusoEmma De FabianiScott W. HiebertMaurizio CrestaniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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Science Q |
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Science Q Alessandra Ferrari Raffaella Longo Erika Fiorino Rui Silva Nico Mitro Gaia Cermenati Federica Gilardi Béatrice Desvergne Annapaola Andolfo Cinzia Magagnotti Donatella Caruso Emma De Fabiani Scott W. Hiebert Maurizio Crestani HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning |
description |
Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning. |
format |
article |
author |
Alessandra Ferrari Raffaella Longo Erika Fiorino Rui Silva Nico Mitro Gaia Cermenati Federica Gilardi Béatrice Desvergne Annapaola Andolfo Cinzia Magagnotti Donatella Caruso Emma De Fabiani Scott W. Hiebert Maurizio Crestani |
author_facet |
Alessandra Ferrari Raffaella Longo Erika Fiorino Rui Silva Nico Mitro Gaia Cermenati Federica Gilardi Béatrice Desvergne Annapaola Andolfo Cinzia Magagnotti Donatella Caruso Emma De Fabiani Scott W. Hiebert Maurizio Crestani |
author_sort |
Alessandra Ferrari |
title |
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning |
title_short |
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning |
title_full |
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning |
title_fullStr |
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning |
title_full_unstemmed |
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning |
title_sort |
hdac3 is a molecular brake of the metabolic switch supporting white adipose tissue browning |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/e79e6f94830242d2a35e5f6ab7dac919 |
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