Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

The serine/threonine kinase WNK1 is an inhibitor of chloride efflux. Here the authors show that this inhibition is a means of negatively regulating the activation of the NLRP3 inflammasome in macrophages, leading to reduced inflammatory responses.

Guardado en:

Detalles Bibliográficos
Autores principales:	Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L. J. Tybulewicz, Teresa Fernandes-Alnemri, Emad S. Alnemri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e7b7e958ca504bdc89a48c00f18c7b6c
record_format	dspace
spelling	oai:doaj.org-article:e7b7e958ca504bdc89a48c00f18c7b6c2021-12-02T16:14:24ZChloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis10.1038/s41467-021-24784-42041-1723https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24784-4https://doaj.org/toc/2041-1723The serine/threonine kinase WNK1 is an inhibitor of chloride efflux. Here the authors show that this inhibition is a means of negatively regulating the activation of the NLRP3 inflammasome in macrophages, leading to reduced inflammatory responses.Lindsey Mayes-HopfingerAura EnacheJian XieChou-Long HuangRobert KöchlVictor L. J. TybulewiczTeresa Fernandes-AlnemriEmad S. AlnemriNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lindsey Mayes-Hopfinger Aura Enache Jian Xie Chou-Long Huang Robert Köchl Victor L. J. Tybulewicz Teresa Fernandes-Alnemri Emad S. Alnemri Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
description	The serine/threonine kinase WNK1 is an inhibitor of chloride efflux. Here the authors show that this inhibition is a means of negatively regulating the activation of the NLRP3 inflammasome in macrophages, leading to reduced inflammatory responses.
format	article
author	Lindsey Mayes-Hopfinger Aura Enache Jian Xie Chou-Long Huang Robert Köchl Victor L. J. Tybulewicz Teresa Fernandes-Alnemri Emad S. Alnemri
author_facet	Lindsey Mayes-Hopfinger Aura Enache Jian Xie Chou-Long Huang Robert Köchl Victor L. J. Tybulewicz Teresa Fernandes-Alnemri Emad S. Alnemri
author_sort	Lindsey Mayes-Hopfinger
title	Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
title_short	Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
title_full	Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
title_fullStr	Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
title_full_unstemmed	Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
title_sort	chloride sensing by wnk1 regulates nlrp3 inflammasome activation and pyroptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6c
work_keys_str_mv	AT lindseymayeshopfinger chloridesensingbywnk1regulatesnlrp3inflammasomeactivationandpyroptosis AT auraenache chloridesensingbywnk1regulatesnlrp3inflammasomeactivationandpyroptosis AT jianxie chloridesensingbywnk1regulatesnlrp3inflammasomeactivationandpyroptosis AT choulonghuang chloridesensingbywnk1regulatesnlrp3inflammasomeactivationandpyroptosis AT robertkochl chloridesensingbywnk1regulatesnlrp3inflammasomeactivationandpyroptosis AT victorljtybulewicz chloridesensingbywnk1regulatesnlrp3inflammasomeactivationandpyroptosis AT teresafernandesalnemri chloridesensingbywnk1regulatesnlrp3inflammasomeactivationandpyroptosis AT emadsalnemri chloridesensingbywnk1regulatesnlrp3inflammasomeactivationandpyroptosis
_version_	1718384324748771328

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

Ejemplares similares