Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

The serine/threonine kinase WNK1 is an inhibitor of chloride efflux. Here the authors show that this inhibition is a means of negatively regulating the activation of the NLRP3 inflammasome in macrophages, leading to reduced inflammatory responses.

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Detalles Bibliográficos
Autores principales: Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L. J. Tybulewicz, Teresa Fernandes-Alnemri, Emad S. Alnemri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6c
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