Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers

Chizuru Konagai,1,2 Kenichi Yanagimoto,3 Kohsuke Hayamizu,3 Li Han,3 Tomoko Tsuji,3 Yoshihiko Koga2 1Department of Food and Nutrition, Japan Women's University, Bunkyo-ku, Tokyo, Japan; 2Department of Neuropsychiatry, Kyorin University School of Medicine, Mitaka, Tokyo, Japan; 3Human Life Sc...

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Autores principales:	Konagai C, Yanagimoto K, Hayamizu K, Han L, Tsuji T, Koga Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) phosphatidylcholine event-relatet potential (ERP) near-infrared spectroscopy (NIRS) dorsolateral prefrontal cortex (DLPFC) Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e7bac93554db4a978e6939fb16d2fcde
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spelling	oai:doaj.org-article:e7bac93554db4a978e6939fb16d2fcde2021-12-02T04:12:26ZEffects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers1178-1998https://doaj.org/article/e7bac93554db4a978e6939fb16d2fcde2013-09-01T00:00:00Zhttps://www.dovepress.com/effects-of-krill-oil-containing-n-3-polyunsaturated-fatty-acids-in-pho-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Chizuru Konagai,1,2 Kenichi Yanagimoto,3 Kohsuke Hayamizu,3 Li Han,3 Tomoko Tsuji,3 Yoshihiko Koga2 1Department of Food and Nutrition, Japan Women's University, Bunkyo-ku, Tokyo, Japan; 2Department of Neuropsychiatry, Kyorin University School of Medicine, Mitaka, Tokyo, Japan; 3Human Life Science R&D Center, Nippon Suisan Kaisha Ltd, Chiyoda-ku, Tokyo, Japan Background: Krill oil, rich in n-3 (omega-3) polyunsaturated fatty acids (PUFAs) incorporated in phosphatidylcholine, has been reported to have many effects on physiological function. However, there are few studies using psychophysiological methods published that describe the effects of krill oil on brain function. We investigated the influence of ingestion of krill oil on cognitive function in elderly subjects by using near-infrared spectroscopy and electroencephalography. Methods: A randomized, double-blind, parallel-group comparative study design was adopted. Forty-five healthy elderly males aged 61–72 years were assigned to receive 12 weeks of treatment with: medium-chain triglycerides as placebo; krill oil, which is rich in n-3 PUFAs incorporated in phosphatidylcholine; or sardine oil, which is abundant in n-3 PUFAs incorporated in triglycerides. Changes in oxyhemoglobin concentrations in the cerebral cortex during memory and calculation tasks were measured. The P300 component of event-related potentials was also measured during a working memory task. Results: During the working memory task, changes in oxyhemoglobin concentrations in the krill oil and sardine oil groups were significantly greater than those in the medium-chain triglyceride group at week 12. The differential value for P300 latency in the krill oil group was significantly lower than that in the medium-chain triglyceride group at week 12. With regard to the calculation task, changes in oxyhemoglobin concentrations in the krill oil group were significantly greater than those in the medium-chain triglyceride group at week 12. Conclusion: This study provides evidence that n-3 PUFAs activate cognitive function in the elderly. This is especially the case with krill oil, in which the majority of n-3 PUFAs are incorporated into phosphatidylcholine, causing it to be more effective than sardine oil, in which n-3 PUFAs are present as triglycerides. Keywords: eicosapentaenoic acid, docosahexaenoic acid, phosphatidylcholine, event-related potential, near-infrared spectroscopy, dorsolateral prefrontal cortexKonagai CYanagimoto KHayamizu KHan LTsuji TKoga YDove Medical Pressarticleeicosapentaenoic acid (EPA)docosahexaenoic acid (DHA)phosphatidylcholineevent-relatet potential (ERP)near-infrared spectroscopy (NIRS)dorsolateral prefrontal cortex (DLPFC)GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1247-1257 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) phosphatidylcholine event-relatet potential (ERP) near-infrared spectroscopy (NIRS) dorsolateral prefrontal cortex (DLPFC) Geriatrics RC952-954.6
spellingShingle	eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) phosphatidylcholine event-relatet potential (ERP) near-infrared spectroscopy (NIRS) dorsolateral prefrontal cortex (DLPFC) Geriatrics RC952-954.6 Konagai C Yanagimoto K Hayamizu K Han L Tsuji T Koga Y Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
description	Chizuru Konagai,1,2 Kenichi Yanagimoto,3 Kohsuke Hayamizu,3 Li Han,3 Tomoko Tsuji,3 Yoshihiko Koga2 1Department of Food and Nutrition, Japan Women's University, Bunkyo-ku, Tokyo, Japan; 2Department of Neuropsychiatry, Kyorin University School of Medicine, Mitaka, Tokyo, Japan; 3Human Life Science R&D Center, Nippon Suisan Kaisha Ltd, Chiyoda-ku, Tokyo, Japan Background: Krill oil, rich in n-3 (omega-3) polyunsaturated fatty acids (PUFAs) incorporated in phosphatidylcholine, has been reported to have many effects on physiological function. However, there are few studies using psychophysiological methods published that describe the effects of krill oil on brain function. We investigated the influence of ingestion of krill oil on cognitive function in elderly subjects by using near-infrared spectroscopy and electroencephalography. Methods: A randomized, double-blind, parallel-group comparative study design was adopted. Forty-five healthy elderly males aged 61–72 years were assigned to receive 12 weeks of treatment with: medium-chain triglycerides as placebo; krill oil, which is rich in n-3 PUFAs incorporated in phosphatidylcholine; or sardine oil, which is abundant in n-3 PUFAs incorporated in triglycerides. Changes in oxyhemoglobin concentrations in the cerebral cortex during memory and calculation tasks were measured. The P300 component of event-related potentials was also measured during a working memory task. Results: During the working memory task, changes in oxyhemoglobin concentrations in the krill oil and sardine oil groups were significantly greater than those in the medium-chain triglyceride group at week 12. The differential value for P300 latency in the krill oil group was significantly lower than that in the medium-chain triglyceride group at week 12. With regard to the calculation task, changes in oxyhemoglobin concentrations in the krill oil group were significantly greater than those in the medium-chain triglyceride group at week 12. Conclusion: This study provides evidence that n-3 PUFAs activate cognitive function in the elderly. This is especially the case with krill oil, in which the majority of n-3 PUFAs are incorporated into phosphatidylcholine, causing it to be more effective than sardine oil, in which n-3 PUFAs are present as triglycerides. Keywords: eicosapentaenoic acid, docosahexaenoic acid, phosphatidylcholine, event-related potential, near-infrared spectroscopy, dorsolateral prefrontal cortex
format	article
author	Konagai C Yanagimoto K Hayamizu K Han L Tsuji T Koga Y
author_facet	Konagai C Yanagimoto K Hayamizu K Han L Tsuji T Koga Y
author_sort	Konagai C
title	Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
title_short	Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
title_full	Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
title_fullStr	Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
title_full_unstemmed	Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
title_sort	effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/e7bac93554db4a978e6939fb16d2fcde
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Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers

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