Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo

Heteroplasmic mitochondrial DNA mutations lack effective treatments. Here the authors adapt I-CreI meganuclease to target the mitochondria and specifically-eliminate mtDNA with a m.5024C>T mutation in the mttRNA Ala gene.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ugne Zekonyte, Sandra R. Bacman, Jeff Smith, Wendy Shoop, Claudia V. Pereira, Ginger Tomberlin, James Stewart, Derek Jantz, Carlos T. Moraes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e7f6099041724090957f81336f63c028
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e7f6099041724090957f81336f63c028
record_format	dspace
spelling	oai:doaj.org-article:e7f6099041724090957f81336f63c0282021-12-02T15:49:30ZMitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo10.1038/s41467-021-23561-72041-1723https://doaj.org/article/e7f6099041724090957f81336f63c0282021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23561-7https://doaj.org/toc/2041-1723Heteroplasmic mitochondrial DNA mutations lack effective treatments. Here the authors adapt I-CreI meganuclease to target the mitochondria and specifically-eliminate mtDNA with a m.5024C>T mutation in the mttRNA Ala gene.Ugne ZekonyteSandra R. BacmanJeff SmithWendy ShoopClaudia V. PereiraGinger TomberlinJames StewartDerek JantzCarlos T. MoraesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ugne Zekonyte Sandra R. Bacman Jeff Smith Wendy Shoop Claudia V. Pereira Ginger Tomberlin James Stewart Derek Jantz Carlos T. Moraes Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
description	Heteroplasmic mitochondrial DNA mutations lack effective treatments. Here the authors adapt I-CreI meganuclease to target the mitochondria and specifically-eliminate mtDNA with a m.5024C>T mutation in the mttRNA Ala gene.
format	article
author	Ugne Zekonyte Sandra R. Bacman Jeff Smith Wendy Shoop Claudia V. Pereira Ginger Tomberlin James Stewart Derek Jantz Carlos T. Moraes
author_facet	Ugne Zekonyte Sandra R. Bacman Jeff Smith Wendy Shoop Claudia V. Pereira Ginger Tomberlin James Stewart Derek Jantz Carlos T. Moraes
author_sort	Ugne Zekonyte
title	Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
title_short	Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
title_full	Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
title_fullStr	Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
title_full_unstemmed	Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
title_sort	mitochondrial targeted meganuclease as a platform to eliminate mutant mtdna in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e7f6099041724090957f81336f63c028
work_keys_str_mv	AT ugnezekonyte mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo AT sandrarbacman mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo AT jeffsmith mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo AT wendyshoop mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo AT claudiavpereira mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo AT gingertomberlin mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo AT jamesstewart mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo AT derekjantz mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo AT carlostmoraes mitochondrialtargetedmeganucleaseasaplatformtoeliminatemutantmtdnainvivo
_version_	1718385724012625920

Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo

Ejemplares similares