Alternative splicing regulates stochastic NLRP3 activity

Leucine-rich repeat (LRR) domains are commonly present in immune regulatory proteins. Here the authors show that LRR exonic modularity and alternative splicing of an LRR-containing protein, NLRP3, modulate the ratio of functional/afunctional NLRP3 isoforms to instill a stochastic regulation of NLRP3...

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Autores principales:	Florian Hoss, James L. Mueller, Francisca Rojas Ringeling, Juan F. Rodriguez-Alcazar, Rebecca Brinkschulte, Gerald Seifert, Rainer Stahl, Lori Broderick, Chris D. Putnam, Richard D. Kolodner, Stefan Canzar, Matthias Geyer, Hal M. Hoffman, Eicke Latz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8556fbf0c984427a366f6b71e4114ec
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spelling	oai:doaj.org-article:e8556fbf0c984427a366f6b71e4114ec2021-12-02T14:39:56ZAlternative splicing regulates stochastic NLRP3 activity10.1038/s41467-019-11076-12041-1723https://doaj.org/article/e8556fbf0c984427a366f6b71e4114ec2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11076-1https://doaj.org/toc/2041-1723Leucine-rich repeat (LRR) domains are commonly present in immune regulatory proteins. Here the authors show that LRR exonic modularity and alternative splicing of an LRR-containing protein, NLRP3, modulate the ratio of functional/afunctional NLRP3 isoforms to instill a stochastic regulation of NLRP3-mediated inflammation and innate immunity.Florian HossJames L. MuellerFrancisca Rojas RingelingJuan F. Rodriguez-AlcazarRebecca BrinkschulteGerald SeifertRainer StahlLori BroderickChris D. PutnamRichard D. KolodnerStefan CanzarMatthias GeyerHal M. HoffmanEicke LatzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian Hoss James L. Mueller Francisca Rojas Ringeling Juan F. Rodriguez-Alcazar Rebecca Brinkschulte Gerald Seifert Rainer Stahl Lori Broderick Chris D. Putnam Richard D. Kolodner Stefan Canzar Matthias Geyer Hal M. Hoffman Eicke Latz Alternative splicing regulates stochastic NLRP3 activity
description	Leucine-rich repeat (LRR) domains are commonly present in immune regulatory proteins. Here the authors show that LRR exonic modularity and alternative splicing of an LRR-containing protein, NLRP3, modulate the ratio of functional/afunctional NLRP3 isoforms to instill a stochastic regulation of NLRP3-mediated inflammation and innate immunity.
format	article
author	Florian Hoss James L. Mueller Francisca Rojas Ringeling Juan F. Rodriguez-Alcazar Rebecca Brinkschulte Gerald Seifert Rainer Stahl Lori Broderick Chris D. Putnam Richard D. Kolodner Stefan Canzar Matthias Geyer Hal M. Hoffman Eicke Latz
author_facet	Florian Hoss James L. Mueller Francisca Rojas Ringeling Juan F. Rodriguez-Alcazar Rebecca Brinkschulte Gerald Seifert Rainer Stahl Lori Broderick Chris D. Putnam Richard D. Kolodner Stefan Canzar Matthias Geyer Hal M. Hoffman Eicke Latz
author_sort	Florian Hoss
title	Alternative splicing regulates stochastic NLRP3 activity
title_short	Alternative splicing regulates stochastic NLRP3 activity
title_full	Alternative splicing regulates stochastic NLRP3 activity
title_fullStr	Alternative splicing regulates stochastic NLRP3 activity
title_full_unstemmed	Alternative splicing regulates stochastic NLRP3 activity
title_sort	alternative splicing regulates stochastic nlrp3 activity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e8556fbf0c984427a366f6b71e4114ec
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Alternative splicing regulates stochastic NLRP3 activity

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