Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor n...

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Main Authors:	Mor R. Alkaslasi, Zoe E. Piccus, Sangeetha Hareendran, Hanna Silberberg, Li Chen, Yajun Zhang, Timothy J. Petros, Claire E. Le Pichon
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/e86a5e80b2b44fef8231c3f0277a9d1f
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spelling	oai:doaj.org-article:e86a5e80b2b44fef8231c3f0277a9d1f2021-12-02T13:41:32ZSingle nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord10.1038/s41467-021-22691-22041-1723https://doaj.org/article/e86a5e80b2b44fef8231c3f0277a9d1f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22691-2https://doaj.org/toc/2041-1723The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor neurons.Mor R. AlkaslasiZoe E. PiccusSangeetha HareendranHanna SilberbergLi ChenYajun ZhangTimothy J. PetrosClaire E. Le PichonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mor R. Alkaslasi Zoe E. Piccus Sangeetha Hareendran Hanna Silberberg Li Chen Yajun Zhang Timothy J. Petros Claire E. Le Pichon Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
description	The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor neurons.
format	article
author	Mor R. Alkaslasi Zoe E. Piccus Sangeetha Hareendran Hanna Silberberg Li Chen Yajun Zhang Timothy J. Petros Claire E. Le Pichon
author_facet	Mor R. Alkaslasi Zoe E. Piccus Sangeetha Hareendran Hanna Silberberg Li Chen Yajun Zhang Timothy J. Petros Claire E. Le Pichon
author_sort	Mor R. Alkaslasi
title	Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_short	Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_full	Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_fullStr	Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_full_unstemmed	Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_sort	single nucleus rna-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e86a5e80b2b44fef8231c3f0277a9d1f
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Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

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