Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function

ABSTRACT Integration of the proviral DNA intermediate into the host cell genome normally represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA is epigenetically silenced. Here, we demonstrate th...

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Autores principales: Ishak D. Irwan, Heather L. Karnowski, Hal P. Bogerd, Kevin Tsai, Bryan R. Cullen
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
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Acceso en línea:https://doaj.org/article/e89049ba44c846f8b00d93509c7f0941
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