Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of <italic toggle="yes">Klebsiella pneumoniae</italic> Carbapenemase-Carrying Plasmids

Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of <italic toggle="yes">Klebsiella pneumoniae</italic> Carbapenemase-Carrying Plasmids

ABSTRACT The rapid dissemination of antimicrobial resistance (AMR) around the globe is largely due to mobile genetic elements, such as plasmids. They confer resistance to critically important drugs, including extended-spectrum beta-lactams, carbapenems, and colistin. Large, complex resistance plasmi...

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Main Authors: Michelle M. C. Buckner, Howard T. H. Saw, Rachael N. Osagie, Alan McNally, Vito Ricci, Matthew E. Wand, Neil Woodford, Alasdair Ivens, Mark A. Webber, Laura J. V. Piddock
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
fitness
Klebsiella pneumoniae carbapenemase (KPC)
genome
pKpQIL
plasmid
transcriptome
Microbiology
QR1-502
Online Access:https://doaj.org/article/e89e885bb47942509854170b9bff404f
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https://doaj.org/article/e89e885bb47942509854170b9bff404f

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