A Predictive Mathematical Modeling Approach for the Study of Doxorubicin Treatment in Triple Negative Breast Cancer

Abstract Doxorubicin forms the basis of chemotherapy regimens for several malignancies, including triple negative breast cancer (TNBC). Here, we present a coupled experimental/modeling approach to establish an in vitro pharmacokinetic/pharmacodynamic model to describe how the concentration and durat...

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Autores principales: Matthew T. McKenna, Jared A. Weis, Stephanie L. Barnes, Darren R. Tyson, Michael I. Miga, Vito Quaranta, Thomas E. Yankeelov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e8a68c155b6c4782a3384e08511f52ab
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