A Predictive Mathematical Modeling Approach for the Study of Doxorubicin Treatment in Triple Negative Breast Cancer

A Predictive Mathematical Modeling Approach for the Study of Doxorubicin Treatment in Triple Negative Breast Cancer

Abstract Doxorubicin forms the basis of chemotherapy regimens for several malignancies, including triple negative breast cancer (TNBC). Here, we present a coupled experimental/modeling approach to establish an in vitro pharmacokinetic/pharmacodynamic model to describe how the concentration and durat...

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Bibliographic Details
Main Authors: Matthew T. McKenna, Jared A. Weis, Stephanie L. Barnes, Darren R. Tyson, Michael I. Miga, Vito Quaranta, Thomas E. Yankeelov
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/e8a68c155b6c4782a3384e08511f52ab
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