Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3

Abstract Dynamic remodelling of the extracellular matrix (ECM) is a key feature of cancer progression. Enzymes that modify the ECM, such as matrix metalloproteinases (MMPs), have long been recognised as important targets of anticancer therapy. Inflammatory cytokines are known to play a key role in r...

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Bibliographic Details
Main Authors: Samuel J. Cutler, James D. Doecke, Ibtisam Ghazawi, Jinbo Yang, Lyn R. Griffiths, Kevin J. Spring, Stephen J. Ralph, Albert S. Mellick
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/e8b635bf4b804c1283b84d769ec90929
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