Binding Heterogeneity of <named-content content-type="genus-species">Plasmodium falciparum</named-content> to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

QR Code

Binding Heterogeneity of <named-content content-type="genus-species">Plasmodium falciparum</named-content> to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

ABSTRACT Cerebral malaria is a severe neurological complication associated with sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the brain microvasculature, but the specific binding interactions remain under debate. Here, we have generated an engineered three-dimensional (3D) hum...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Maria Bernabeu, Celina Gunnarsson, Maria Vishnyakova, Caitlin C. Howard, Ryan J. Nagao, Marion Avril, Terrie E. Taylor, Karl B. Seydel, Ying Zheng, Joseph D. Smith
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2019
Sujets:	PfEMP1 Plasmodium falciparum cerebral malaria microvessels tissue engineering Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/e8baabff64bb490f8a669a8d2a19155f
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Meta-analysis of <named-content content-type="genus-species">Plasmodium falciparum</named-content> <italic toggle="yes">var</italic> Signatures Contributing to Severe Malaria in African Children and Indian Adults
par: Fergal Duffy, et autres
Publié: (2019)

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine
par: Rebecca Webster, et autres
Publié: (2021)

<named-content content-type="genus-species">Plasmodium falciparum</named-content> Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation
par: Kirthana M. V. Sindhe, et autres
Publié: (2020)

mSphere of Influence: Going Native, or the Risk of Overreliance on Recombinant Antigens
par: Mary Lopez-Perez
Publié: (2020)

Pathogenicity Determinants of the Human Malaria Parasite <named-content content-type="genus-species">Plasmodium falciparum</named-content> Have Ancient Origins
par: Andrew J. Brazier, et autres
Publié: (2017)

Role of <named-content content-type="genus-species">Plasmodium falciparum</named-content> Kelch 13 Protein Mutations in <named-content content-type="genus-species">P. falciparum</named-content> Populations from Northeastern Myanmar in Mediating Artemisinin Resistance
par: Faiza Amber Siddiqui, et autres
Publié: (2020)

Dispensable Role of Mitochondrial Fission Protein 1 (Fis1) in the Erythrocytic Development of <named-content content-type="genus-species">Plasmodium falciparum</named-content>
par: Mulaka Maruthi, et autres
Publié: (2020)

Radicicol-Mediated Inhibition of Topoisomerase VIB-VIA Activity of the Human Malaria Parasite <named-content content-type="genus-species">Plasmodium falciparum</named-content>
par: Sureshkumar Chalapareddy, et autres
Publié: (2016)

The Exported Chaperone PfHsp70x Is Dispensable for the <named-content content-type="genus-species">Plasmodium falciparum</named-content> Intraerythrocytic Life Cycle
par: David W. Cobb, et autres
Publié: (2017)

<named-content content-type="genus-species">Plasmodium berghei</named-content> K13 Mutations Mediate <italic toggle="yes">In Vivo</italic> Artemisinin Resistance That Is Reversed by Proteasome Inhibition
par: Nelson V. Simwela, et autres
Publié: (2020)

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in <named-content content-type="genus-species">Plasmodium falciparum</named-content>
par: Laure Dumont, et autres
Publié: (2019)

Protein Kinase A Is Essential for Invasion of <named-content content-type="genus-species">Plasmodium falciparum</named-content> into Human Erythrocytes
par: Mary-Louise Wilde, et autres
Publié: (2019)

Targeted Phenotypic Screening in <named-content content-type="genus-species">Plasmodium falciparum</named-content> and <named-content content-type="genus-species">Toxoplasma gondii</named-content> Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules
par: Gowtham Subramanian, et autres
Publié: (2018)

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on <named-content content-type="genus-species">Plasmodium falciparum</named-content> Multidrug Resistance and Fitness
par: Satish K. Dhingra, et autres
Publié: (2019)

A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the <named-content content-type="genus-species">Plasmodium falciparum</named-content> Life Cycle
par: Marta Tibúrcio, et autres
Publié: (2019)

Influence of <named-content content-type="genus-species">Plasmodium falciparum</named-content> Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome
par: Karin Blomqvist, et autres
Publié: (2020)

Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase
par: Niranjan Suthram, et autres
Publié: (2020)

Genetic Markers of Adaptation of <named-content content-type="genus-species">Plasmodium falciparum</named-content> to Transmission by American Vectors Identified in the Genomes of Parasites from Haiti and South America
par: Massimiliano S. Tagliamonte, et autres
Publié: (2020)

Single-Cell Analysis Reveals Distinct Gene Expression and Heterogeneity in Male and Female <named-content content-type="genus-species">Plasmodium falciparum</named-content> Gametocytes
par: Katelyn A. Walzer, et autres
Publié: (2018)

The Structure of the Cysteine-Rich Domain of <named-content content-type="genus-species">Plasmodium falciparum</named-content> P113 Identifies the Location of the RH5 Binding Site
par: Ivan Campeotto, et autres
Publié: (2020)

Expression Patterns of <named-content content-type="genus-species">Plasmodium falciparum</named-content> Clonally Variant Genes at the Onset of a Blood Infection in Malaria-Naive Humans
par: Anastasia K. Pickford, et autres
Publié: (2021)

THE CIDR1α-PfEMP1 SEQUENCE FROM INDONESIAN PLASMODIUM FALCIPARUM AND ITS POTENTIAL ASSOCIATION WITH THE CEREBRAL OUTCOME
par: Erma Sulistyaningsih, et autres
Publié: (2021)

<named-content content-type="genus-species">Plasmodium falciparum</named-content> Apicomplexan-Specific Glucosamine-6-Phosphate <italic toggle="yes">N</italic>-Acetyltransferase Is Key for Amino Sugar Metabolism and Asexual Blood Stage Development
par: Jordi Chi, et autres
Publié: (2020)

Expansion of a Specific <named-content content-type="genus-species">Plasmodium falciparum</named-content> PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport
par: Carla Calçada, et autres
Publié: (2020)

CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of <italic toggle="yes">var</italic> Genes in <named-content content-type="genus-species">Plasmodium falciparum</named-content>
par: Anna Barcons-Simon, et autres
Publié: (2020)

Malaria: revisión retrospectiva de 12 casos no autóctonos en Chile
par: Pérez C,Carlos, et autres
Publié: (2006)

Overexpression of <i>Plasmodium falciparum</i> M1 Aminopeptidase Promotes an Increase in Intracellular Proteolysis and Modifies the Asexual Erythrocytic Cycle Development
par: Carolina C. Hoff, et autres
Publié: (2021)

A Variant PfCRT Isoform Can Contribute to <italic toggle="yes">Plasmodium falciparum</italic> Resistance to the First-Line Partner Drug Piperaquine
par: Satish K. Dhingra, et autres
Publié: (2017)

Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis
par: Feng Guangui, et autres
Publié: (2021)

Pf Filamentous Phage Requires UvrD for Replication in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>
par: Eriel Martínez, et autres
Publié: (2016)

Internalization of Erythrocyte Acylpeptide Hydrolase Is Required for Asexual Replication of <named-content content-type="genus-species">Plasmodium falciparum</named-content>
par: Rubayet Elahi, et autres
Publié: (2019)

MALARIA IN ANCIENT EGYPT: PALEOIMMUNOLOGICAL INVESTIGATION ON PREDYNASTIC MUMMIFIED REMAINS
par: Rabino Massa,Emma, et autres
Publié: (2000)

Malaria por Plasmodium falciparum en el servicio de medicina del Hospital San Camilo de San Felipe
par: WILSON,GONZALO, et autres
Publié: (2006)

Identification of an Immunogenic Broadly Inhibitory Surface Epitope of the <named-content content-type="genus-species">Plasmodium vivax</named-content> Duffy Binding Protein Ligand Domain
par: Miriam T. George, et autres
Publié: (2019)

Malaria congénita por Plasmodium falciparum
par: Del Castillo Calderón,José Gabriel, et autres
Publié: (2020)

Immune Response and Microbiota Profiles during Coinfection with <named-content content-type="genus-species">Plasmodium vivax</named-content> and Soil-Transmitted Helminths
par: Alice V. Easton, et autres
Publié: (2020)

Nuclear, Cytosolic, and Surface-Localized Poly(A)-Binding Proteins of <named-content content-type="genus-species">Plasmodium yoelii</named-content>
par: Allen M. Minns, et autres
Publié: (2018)

20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in <named-content content-type="genus-species">Anopheles gambiae</named-content>
par: Rebekah A. Reynolds, et autres
Publié: (2020)

A <named-content content-type="genus-species">Toxoplasma gondii</named-content> Ortholog of <italic toggle="yes">Plasmodium</italic> GAMA Contributes to Parasite Attachment and Cell Invasion
par: My-Hang Huynh, et autres
Publié: (2016)

<named-content content-type="genus-species">Plasmodium yoelii</named-content> Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity
par: Yu-chih Peng, et autres
Publié: (2020)