A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumo...
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Nature Portfolio
2021
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oai:doaj.org-article:e91c50b481d241a5a03c46be3e14769c2021-12-02T15:10:47ZA highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy10.1038/s41467-021-25303-12041-1723https://doaj.org/article/e91c50b481d241a5a03c46be3e14769c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25303-1https://doaj.org/toc/2041-1723Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumors effectively.Chao LiangJiaen XieShuangling LuoCan HuangQianling ZhangHuaiyi HuangPingyu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021) |
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Science Q Chao Liang Jiaen Xie Shuangling Luo Can Huang Qianling Zhang Huaiyi Huang Pingyu Zhang A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy |
description |
Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumors effectively. |
format |
article |
author |
Chao Liang Jiaen Xie Shuangling Luo Can Huang Qianling Zhang Huaiyi Huang Pingyu Zhang |
author_facet |
Chao Liang Jiaen Xie Shuangling Luo Can Huang Qianling Zhang Huaiyi Huang Pingyu Zhang |
author_sort |
Chao Liang |
title |
A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy |
title_short |
A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy |
title_full |
A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy |
title_fullStr |
A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy |
title_full_unstemmed |
A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy |
title_sort |
highly potent ruthenium(ii)-sonosensitizer and sonocatalyst for in vivo sonotherapy |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/e91c50b481d241a5a03c46be3e14769c |
work_keys_str_mv |
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