A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumo...

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Autores principales: Chao Liang, Jiaen Xie, Shuangling Luo, Can Huang, Qianling Zhang, Huaiyi Huang, Pingyu Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e91c50b481d241a5a03c46be3e14769c
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spelling oai:doaj.org-article:e91c50b481d241a5a03c46be3e14769c2021-12-02T15:10:47ZA highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy10.1038/s41467-021-25303-12041-1723https://doaj.org/article/e91c50b481d241a5a03c46be3e14769c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25303-1https://doaj.org/toc/2041-1723Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumors effectively.Chao LiangJiaen XieShuangling LuoCan HuangQianling ZhangHuaiyi HuangPingyu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chao Liang
Jiaen Xie
Shuangling Luo
Can Huang
Qianling Zhang
Huaiyi Huang
Pingyu Zhang
A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
description Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumors effectively.
format article
author Chao Liang
Jiaen Xie
Shuangling Luo
Can Huang
Qianling Zhang
Huaiyi Huang
Pingyu Zhang
author_facet Chao Liang
Jiaen Xie
Shuangling Luo
Can Huang
Qianling Zhang
Huaiyi Huang
Pingyu Zhang
author_sort Chao Liang
title A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_short A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_full A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_fullStr A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_full_unstemmed A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_sort highly potent ruthenium(ii)-sonosensitizer and sonocatalyst for in vivo sonotherapy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e91c50b481d241a5a03c46be3e14769c
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