A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumo...

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Autores principales:	Chao Liang, Jiaen Xie, Shuangling Luo, Can Huang, Qianling Zhang, Huaiyi Huang, Pingyu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e91c50b481d241a5a03c46be3e14769c
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spelling	oai:doaj.org-article:e91c50b481d241a5a03c46be3e14769c2021-12-02T15:10:47ZA highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy10.1038/s41467-021-25303-12041-1723https://doaj.org/article/e91c50b481d241a5a03c46be3e14769c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25303-1https://doaj.org/toc/2041-1723Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumors effectively.Chao LiangJiaen XieShuangling LuoCan HuangQianling ZhangHuaiyi HuangPingyu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Liang Jiaen Xie Shuangling Luo Can Huang Qianling Zhang Huaiyi Huang Pingyu Zhang A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
description	Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumors effectively.
format	article
author	Chao Liang Jiaen Xie Shuangling Luo Can Huang Qianling Zhang Huaiyi Huang Pingyu Zhang
author_facet	Chao Liang Jiaen Xie Shuangling Luo Can Huang Qianling Zhang Huaiyi Huang Pingyu Zhang
author_sort	Chao Liang
title	A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_short	A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_full	A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_fullStr	A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_full_unstemmed	A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
title_sort	highly potent ruthenium(ii)-sonosensitizer and sonocatalyst for in vivo sonotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e91c50b481d241a5a03c46be3e14769c
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A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

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