Structural basis for plazomicin antibiotic action and resistance

Golkar, Bassenden et al. report two structures of the latest generation aminoglycoside antibiotic plazomicin in complex with the bacterial 70S ribosome as well as in complex with AAC(2’)-la acetyltransferase, an antibiotic modification enzyme (AME). Their study can be useful in the development of ne...

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Autores principales:	Tolou Golkar, Angelia V. Bassenden, Krishnagopal Maiti, Dev P. Arya, T. Martin Schmeing, Albert M. Berghuis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e920b775f2c646bfaee3171a047210be
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spelling	oai:doaj.org-article:e920b775f2c646bfaee3171a047210be2021-12-02T17:47:03ZStructural basis for plazomicin antibiotic action and resistance10.1038/s42003-021-02261-42399-3642https://doaj.org/article/e920b775f2c646bfaee3171a047210be2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02261-4https://doaj.org/toc/2399-3642Golkar, Bassenden et al. report two structures of the latest generation aminoglycoside antibiotic plazomicin in complex with the bacterial 70S ribosome as well as in complex with AAC(2’)-la acetyltransferase, an antibiotic modification enzyme (AME). Their study can be useful in the development of newer aminoglycosides that are not modified by AMEs while being capable of targeting the bacterial ribosome.Tolou GolkarAngelia V. BassendenKrishnagopal MaitiDev P. AryaT. Martin SchmeingAlbert M. BerghuisNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tolou Golkar Angelia V. Bassenden Krishnagopal Maiti Dev P. Arya T. Martin Schmeing Albert M. Berghuis Structural basis for plazomicin antibiotic action and resistance
description	Golkar, Bassenden et al. report two structures of the latest generation aminoglycoside antibiotic plazomicin in complex with the bacterial 70S ribosome as well as in complex with AAC(2’)-la acetyltransferase, an antibiotic modification enzyme (AME). Their study can be useful in the development of newer aminoglycosides that are not modified by AMEs while being capable of targeting the bacterial ribosome.
format	article
author	Tolou Golkar Angelia V. Bassenden Krishnagopal Maiti Dev P. Arya T. Martin Schmeing Albert M. Berghuis
author_facet	Tolou Golkar Angelia V. Bassenden Krishnagopal Maiti Dev P. Arya T. Martin Schmeing Albert M. Berghuis
author_sort	Tolou Golkar
title	Structural basis for plazomicin antibiotic action and resistance
title_short	Structural basis for plazomicin antibiotic action and resistance
title_full	Structural basis for plazomicin antibiotic action and resistance
title_fullStr	Structural basis for plazomicin antibiotic action and resistance
title_full_unstemmed	Structural basis for plazomicin antibiotic action and resistance
title_sort	structural basis for plazomicin antibiotic action and resistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e920b775f2c646bfaee3171a047210be
work_keys_str_mv	AT tolougolkar structuralbasisforplazomicinantibioticactionandresistance AT angeliavbassenden structuralbasisforplazomicinantibioticactionandresistance AT krishnagopalmaiti structuralbasisforplazomicinantibioticactionandresistance AT devparya structuralbasisforplazomicinantibioticactionandresistance AT tmartinschmeing structuralbasisforplazomicinantibioticactionandresistance AT albertmberghuis structuralbasisforplazomicinantibioticactionandresistance
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Structural basis for plazomicin antibiotic action and resistance

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