High efficacy in vitro selection procedure for generating transgenic parasites of Plasmodium berghei using an antibiotic toxic to rodent hosts

Abstract The malaria parasite Plasmodium berghei is one of the main rodent malaria models. A shortcoming of this model parasite is its low flexibility in genetic manipulation. As this parasite cannot be continuously propagated in cell cultures, in vivo drug selection procedures are necessary to isol...

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Autores principales: Akira Soga, Hironori Bando, Mami Ko-ketsu, Hirono Masuda-Suganuma, Shin-ichiro Kawazu, Shinya Fukumoto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e952a447d54247978f819451a93f4600
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