The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice
Auxin-inducible degron systems can be leaky and require high doses of auxin. Here the authors establish AID2 which uses an OsTIR1 mutant and the ligand 5-Ph-IAA to overcome these problems and establish AID-mediated target depletion in mice.
Saved in:
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/e96ad288aa7749f7bdb3f1e9cc207dea |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|