Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Abstract Background Wolfram syndrome (WFS) is a rare autosomal recessive syndrome in which diabetes mellitus and neurodegenerative disorders occur as a result of Wolframin deficiency and increased ER stress. In addition, WFS1 deficiency leads to calcium homeostasis disturbances and can change mitoch...

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Autores principales: Agnieszka Zmyslowska, Miljan Kuljanin, Beata Malachowska, Marcin Stanczak, Dominika Michalek, Aneta Wlodarczyk, Dagmara Grot, Joanna Taha, Bartłomiej Pawlik, Magdalena Lebiedzińska-Arciszewska, Hanna Nieznanska, Mariusz R. Wieckowski, Piotr Rieske, Joseph D. Mancias, Maciej Borowiec, Wojciech Mlynarski, Wojciech Fendler
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Wolfram syndrome
Proteomics
Transcriptomics
Mitochondria
ER stress
Medicine
R
Cytology
QH573-671
Acceso en línea:https://doaj.org/article/e9ae24e4ded347729d7a31887a6ccfdf
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