Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies

Cellular heterogeneity is one of the major confounding factors in EWAS studies. Here the authors present a statistical method, HIgh REsolution (HIRE), which enables the detection of risk-CpG sites for individual cell types.

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Bibliographic Details
Main Authors:	Xiangyu Luo, Can Yang, Yingying Wei
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/e9cc3f68adb44c948f64c6906ceaed6d
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spelling	oai:doaj.org-article:e9cc3f68adb44c948f64c6906ceaed6d2021-12-02T17:02:08ZDetection of cell-type-specific risk-CpG sites in epigenome-wide association studies10.1038/s41467-019-10864-z2041-1723https://doaj.org/article/e9cc3f68adb44c948f64c6906ceaed6d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10864-zhttps://doaj.org/toc/2041-1723Cellular heterogeneity is one of the major confounding factors in EWAS studies. Here the authors present a statistical method, HIgh REsolution (HIRE), which enables the detection of risk-CpG sites for individual cell types.Xiangyu LuoCan YangYingying WeiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiangyu Luo Can Yang Yingying Wei Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
description	Cellular heterogeneity is one of the major confounding factors in EWAS studies. Here the authors present a statistical method, HIgh REsolution (HIRE), which enables the detection of risk-CpG sites for individual cell types.
format	article
author	Xiangyu Luo Can Yang Yingying Wei
author_facet	Xiangyu Luo Can Yang Yingying Wei
author_sort	Xiangyu Luo
title	Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
title_short	Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
title_full	Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
title_fullStr	Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
title_full_unstemmed	Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
title_sort	detection of cell-type-specific risk-cpg sites in epigenome-wide association studies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e9cc3f68adb44c948f64c6906ceaed6d
work_keys_str_mv	AT xiangyuluo detectionofcelltypespecificriskcpgsitesinepigenomewideassociationstudies AT canyang detectionofcelltypespecificriskcpgsitesinepigenomewideassociationstudies AT yingyingwei detectionofcelltypespecificriskcpgsitesinepigenomewideassociationstudies
_version_	1718382002203262976

Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies

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