Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

Summary: Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and T cell motility via LPAR2, yet its actions in the tumor immune microen...

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Autores principales: Elisa Matas-Rico, Elselien Frijlink, Irene van der Haar Àvila, Apostolos Menegakis, Maaike van Zon, Andrew J. Morris, Jan Koster, Fernando Salgado-Polo, Sander de Kivit, Telma Lança, Antonio Mazzocca, Zoë Johnson, John Haanen, Ton N. Schumacher, Anastassis Perrakis, Inge Verbrugge, Joost H. van den Berg, Jannie Borst, Wouter H. Moolenaar
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
lysophosphatidic acid
autotaxin
chemorepulsion
T cells
G protein-coupled receptors
tumor microenvironment
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/e9e9408a389a42bbba3e0b1045703cf7
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https://doaj.org/article/e9e9408a389a42bbba3e0b1045703cf7

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