Angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats

Introduction: Cisplatin (CP) is an anti-cancer drug with the most common side effects of nephrotoxicity. Losartan, an angiotensin II type 1 receptor (AT1R) antagonist and angiotensin 1-7 (Ang1-7) protects the kidney against CP administration in males Moreover, the activity of the renin angiotensin s...

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Autores principales:	Sayyedehnikta Kasaei, Zahra Pezeshki, Farzaneh Karimi, Zahra Lak, Samira Choopani, Ardeshir Talebi, Mehdi Nematbakhsh
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2022
Materias:	angiotensin 1-7 losartan cisplatin Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/ea0645b4b1904d5093f609349facec66
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spelling	oai:doaj.org-article:ea0645b4b1904d5093f609349facec662021-11-17T08:15:00ZAngiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats2345-420210.34172/npj.2022.10https://doaj.org/article/ea0645b4b1904d5093f609349facec662022-01-01T00:00:00Zhttps://jnephropharmacology.com/PDF/npj-10380https://doaj.org/toc/2345-4202Introduction: Cisplatin (CP) is an anti-cancer drug with the most common side effects of nephrotoxicity. Losartan, an angiotensin II type 1 receptor (AT1R) antagonist and angiotensin 1-7 (Ang1-7) protects the kidney against CP administration in males Moreover, the activity of the renin angiotensin system (RAS) and the incidence of CP induced nephrotoxicity are gender related. Objectives: The role of Ang1-7 and losartan against CP induced nephrotoxicity in female rats was examined. Methods: Thirty-two female Wistar rats in five experimental groups were treated with vehicle, single dose of CP (7.5 mg/kg), CP+losartan (10 ), CP+Ang1-7 (30 μg/kg/d) or CP+Ang1-7+A779 (Mas receptor antagonist, 100 μg/kg/d). The biochemical and histology measurements were conducted one week later. Results: The levels of serum creatinine (Cr) and blood urea nitrogen (BUN) in serum increased insignificantly by CP alone administration. However co-treatment of CP with losartan, Ang1-7, or Ang1-7 plus A779 showed an increase of the serum levels of BUN and Cr, and kidney tissue damage score (KTDS) (P < 0.05) when compared with control groups. Conclusion: The AT1R and Mas receptor (MasR) antagonists and Ang1-7 administration promote the CP induced damage of kidney in female rats, and special attention is needed during CP therapy in hypertensive patients who are treating with anti-hypertensive drug of losartan.Sayyedehnikta KasaeiZahra PezeshkiFarzaneh KarimiZahra LakSamira ChoopaniArdeshir TalebiMehdi NematbakhshSociety of Diabetic Nephropathy Prevention articleangiotensin 1-7losartancisplatinTherapeutics. PharmacologyRM1-950Diseases of the genitourinary system. UrologyRC870-923ENJournal of Nephropharmacology, Vol 11, Iss 1, Pp e10-e10 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiotensin 1-7 losartan cisplatin Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	angiotensin 1-7 losartan cisplatin Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923 Sayyedehnikta Kasaei Zahra Pezeshki Farzaneh Karimi Zahra Lak Samira Choopani Ardeshir Talebi Mehdi Nematbakhsh Angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats
description	Introduction: Cisplatin (CP) is an anti-cancer drug with the most common side effects of nephrotoxicity. Losartan, an angiotensin II type 1 receptor (AT1R) antagonist and angiotensin 1-7 (Ang1-7) protects the kidney against CP administration in males Moreover, the activity of the renin angiotensin system (RAS) and the incidence of CP induced nephrotoxicity are gender related. Objectives: The role of Ang1-7 and losartan against CP induced nephrotoxicity in female rats was examined. Methods: Thirty-two female Wistar rats in five experimental groups were treated with vehicle, single dose of CP (7.5 mg/kg), CP+losartan (10 ), CP+Ang1-7 (30 μg/kg/d) or CP+Ang1-7+A779 (Mas receptor antagonist, 100 μg/kg/d). The biochemical and histology measurements were conducted one week later. Results: The levels of serum creatinine (Cr) and blood urea nitrogen (BUN) in serum increased insignificantly by CP alone administration. However co-treatment of CP with losartan, Ang1-7, or Ang1-7 plus A779 showed an increase of the serum levels of BUN and Cr, and kidney tissue damage score (KTDS) (P < 0.05) when compared with control groups. Conclusion: The AT1R and Mas receptor (MasR) antagonists and Ang1-7 administration promote the CP induced damage of kidney in female rats, and special attention is needed during CP therapy in hypertensive patients who are treating with anti-hypertensive drug of losartan.
format	article
author	Sayyedehnikta Kasaei Zahra Pezeshki Farzaneh Karimi Zahra Lak Samira Choopani Ardeshir Talebi Mehdi Nematbakhsh
author_facet	Sayyedehnikta Kasaei Zahra Pezeshki Farzaneh Karimi Zahra Lak Samira Choopani Ardeshir Talebi Mehdi Nematbakhsh
author_sort	Sayyedehnikta Kasaei
title	Angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats
title_short	Angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats
title_full	Angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats
title_fullStr	Angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats
title_full_unstemmed	Angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats
title_sort	angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2022
url	https://doaj.org/article/ea0645b4b1904d5093f609349facec66
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Angiotensin 1-7 and losartan worsen the cisplatin induced nephrotoxicity in female rats

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