Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor.

Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor.

ρ-Da1a is a three-finger fold toxin from green mamba venom that is highly selective for the α1A-adrenoceptor. This toxin has atypical pharmacological properties, including incomplete inhibition of (3)H-prazosin or (125)I-HEAT binding and insurmountable antagonist action. We aimed to clarify its mode...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Arhamatoulaye Maïga, Jon Merlin, Elodie Marcon, Céline Rouget, Maud Larregola, Bernard Gilquin, Carole Fruchart-Gaillard, Evelyne Lajeunesse, Charles Marchetti, Alain Lorphelin, Laurent Bellanger, Roger J Summers, Dana S Hutchinson, Bronwyn A Evans, Denis Servent, Nicolas Gilles
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/ea1b5de2a53b4c798bdec40a54b07f16
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/ea1b5de2a53b4c798bdec40a54b07f16

Documents similaires