SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: David Walter, Saskia Hoffmann, Eirini-Stavroula Komseli, Juri Rappsilber, Vassilis Gorgoulis, Claus Storgaard Sørensen
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
Q
Accès en ligne:https://doaj.org/article/ea2c7f82640b4cec8dd591558f03042e
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!