SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.
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Auteurs principaux: | , , , , , |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2016
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Accès en ligne: | https://doaj.org/article/ea2c7f82640b4cec8dd591558f03042e |
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