SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.

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Autores principales:	David Walter, Saskia Hoffmann, Eirini-Stavroula Komseli, Juri Rappsilber, Vassilis Gorgoulis, Claus Storgaard Sørensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea2c7f82640b4cec8dd591558f03042e
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spelling	oai:doaj.org-article:ea2c7f82640b4cec8dd591558f03042e2021-12-02T15:34:31ZSCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication10.1038/ncomms105302041-1723https://doaj.org/article/ea2c7f82640b4cec8dd591558f03042e2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10530https://doaj.org/toc/2041-1723To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.David WalterSaskia HoffmannEirini-Stavroula KomseliJuri RappsilberVassilis GorgoulisClaus Storgaard SørensenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Walter Saskia Hoffmann Eirini-Stavroula Komseli Juri Rappsilber Vassilis Gorgoulis Claus Storgaard Sørensen SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
description	To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.
format	article
author	David Walter Saskia Hoffmann Eirini-Stavroula Komseli Juri Rappsilber Vassilis Gorgoulis Claus Storgaard Sørensen
author_facet	David Walter Saskia Hoffmann Eirini-Stavroula Komseli Juri Rappsilber Vassilis Gorgoulis Claus Storgaard Sørensen
author_sort	David Walter
title	SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
title_short	SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
title_full	SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
title_fullStr	SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
title_full_unstemmed	SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
title_sort	scfcyclin f-dependent degradation of cdc6 suppresses dna re-replication
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ea2c7f82640b4cec8dd591558f03042e
work_keys_str_mv	AT davidwalter scfcyclinfdependentdegradationofcdc6suppressesdnarereplication AT saskiahoffmann scfcyclinfdependentdegradationofcdc6suppressesdnarereplication AT eirinistavroulakomseli scfcyclinfdependentdegradationofcdc6suppressesdnarereplication AT jurirappsilber scfcyclinfdependentdegradationofcdc6suppressesdnarereplication AT vassilisgorgoulis scfcyclinfdependentdegradationofcdc6suppressesdnarereplication AT clausstorgaardsørensen scfcyclinfdependentdegradationofcdc6suppressesdnarereplication
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SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

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