SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.

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Autores principales: David Walter, Saskia Hoffmann, Eirini-Stavroula Komseli, Juri Rappsilber, Vassilis Gorgoulis, Claus Storgaard Sørensen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ea2c7f82640b4cec8dd591558f03042e
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