Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

The orphan nuclear receptor COUP-TFII is highly expressed in metastatic prostate cancers and its overexpression accelerates prostate tumour progression in mouse models. Here, the author show that that loss of miR-101 and miR-27a in prostate cancer cells can lead to COUP-TFII expression which in turn...

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Autores principales:	Shih-Chieh Lin, Chung-Yang Kao, Hui-Ju Lee, Chad J. Creighton, Michael M. Ittmann, Shaw-Jenq Tsai, Sophia Y. Tsai, Ming-Jer Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea77da78abb94d3e818aa812c14677ef
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spelling	oai:doaj.org-article:ea77da78abb94d3e818aa812c14677ef2021-12-02T16:49:26ZDysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer10.1038/ncomms114182041-1723https://doaj.org/article/ea77da78abb94d3e818aa812c14677ef2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11418https://doaj.org/toc/2041-1723The orphan nuclear receptor COUP-TFII is highly expressed in metastatic prostate cancers and its overexpression accelerates prostate tumour progression in mouse models. Here, the author show that that loss of miR-101 and miR-27a in prostate cancer cells can lead to COUP-TFII expression which in turn directly regulates FOXM1 and CENPFfavouring prostate cancer metastasis.Shih-Chieh LinChung-Yang KaoHui-Ju LeeChad J. CreightonMichael M. IttmannShaw-Jenq TsaiSophia Y. TsaiMing-Jer TsaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shih-Chieh Lin Chung-Yang Kao Hui-Ju Lee Chad J. Creighton Michael M. Ittmann Shaw-Jenq Tsai Sophia Y. Tsai Ming-Jer Tsai Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
description	The orphan nuclear receptor COUP-TFII is highly expressed in metastatic prostate cancers and its overexpression accelerates prostate tumour progression in mouse models. Here, the author show that that loss of miR-101 and miR-27a in prostate cancer cells can lead to COUP-TFII expression which in turn directly regulates FOXM1 and CENPFfavouring prostate cancer metastasis.
format	article
author	Shih-Chieh Lin Chung-Yang Kao Hui-Ju Lee Chad J. Creighton Michael M. Ittmann Shaw-Jenq Tsai Sophia Y. Tsai Ming-Jer Tsai
author_facet	Shih-Chieh Lin Chung-Yang Kao Hui-Ju Lee Chad J. Creighton Michael M. Ittmann Shaw-Jenq Tsai Sophia Y. Tsai Ming-Jer Tsai
author_sort	Shih-Chieh Lin
title	Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
title_short	Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
title_full	Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
title_fullStr	Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
title_full_unstemmed	Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
title_sort	dysregulation of mirnas-coup-tfii-foxm1-cenpf axis contributes to the metastasis of prostate cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ea77da78abb94d3e818aa812c14677ef
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Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

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