HIV-1 Vpr-Induced Proinflammatory Response and Apoptosis Are Mediated through the Sur1-Trpm4 Channel in Astrocytes

ABSTRACT Successful treatment of HIV-infected patients with combinational antiretroviral therapies (cART) can now prolong patients’ lives to nearly normal life spans. However, the new challenge faced by many of those HIV-infected patients is chronic neuroinflammation and neurotoxicity that often lea...

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Autores principales: Ge Li, Tapas Makar, Volodymyr Gerzanich, Sudhakar Kalakonda, Svetlana Ivanova, Edna F. R. Pereira, Sanketh Andharvarapu, Jiantao Zhang, J. Marc Simard, Richard Y. Zhao
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
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Acceso en línea:https://doaj.org/article/ea8b4ab945e34b9381587cff74289f97
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