Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice and show that a DLL4/NOTCH1/VEGFA/VEGFR2 signalin...

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Autores principales:	Yidong Wang, Bingruo Wu, Pengfei Lu, Donghong Zhang, Brian Wu, Shweta Varshney, Gonzalo del Monte-Nieto, Zhenwu Zhuang, Rabab Charafeddine, Adam H. Kramer, Nicolas E. Sibinga, Nikolaos G. Frangogiannis, Richard N. Kitsis, Ralf H. Adams, Kari Alitalo, David J. Sharp, Richard P. Harvey, Pamela Stanley, Bin Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea93cbead9a042ce807dbd39e7d1c160
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spelling	oai:doaj.org-article:ea93cbead9a042ce807dbd39e7d1c1602021-12-02T14:40:45ZUncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut110.1038/s41467-017-00654-w2041-1723https://doaj.org/article/ea93cbead9a042ce807dbd39e7d1c1602017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00654-whttps://doaj.org/toc/2041-1723Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice and show that a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis is key for coronary artery development.Yidong WangBingruo WuPengfei LuDonghong ZhangBrian WuShweta VarshneyGonzalo del Monte-NietoZhenwu ZhuangRabab CharafeddineAdam H. KramerNicolas E. SibingaNikolaos G. FrangogiannisRichard N. KitsisRalf H. AdamsKari AlitaloDavid J. SharpRichard P. HarveyPamela StanleyBin ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yidong Wang Bingruo Wu Pengfei Lu Donghong Zhang Brian Wu Shweta Varshney Gonzalo del Monte-Nieto Zhenwu Zhuang Rabab Charafeddine Adam H. Kramer Nicolas E. Sibinga Nikolaos G. Frangogiannis Richard N. Kitsis Ralf H. Adams Kari Alitalo David J. Sharp Richard P. Harvey Pamela Stanley Bin Zhou Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
description	Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice and show that a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis is key for coronary artery development.
format	article
author	Yidong Wang Bingruo Wu Pengfei Lu Donghong Zhang Brian Wu Shweta Varshney Gonzalo del Monte-Nieto Zhenwu Zhuang Rabab Charafeddine Adam H. Kramer Nicolas E. Sibinga Nikolaos G. Frangogiannis Richard N. Kitsis Ralf H. Adams Kari Alitalo David J. Sharp Richard P. Harvey Pamela Stanley Bin Zhou
author_facet	Yidong Wang Bingruo Wu Pengfei Lu Donghong Zhang Brian Wu Shweta Varshney Gonzalo del Monte-Nieto Zhenwu Zhuang Rabab Charafeddine Adam H. Kramer Nicolas E. Sibinga Nikolaos G. Frangogiannis Richard N. Kitsis Ralf H. Adams Kari Alitalo David J. Sharp Richard P. Harvey Pamela Stanley Bin Zhou
author_sort	Yidong Wang
title	Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
title_short	Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
title_full	Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
title_fullStr	Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
title_full_unstemmed	Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
title_sort	uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking pofut1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ea93cbead9a042ce807dbd39e7d1c160
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Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

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