Rap1 and Cdc13 have complementary roles in preventing exonucleolytic degradation of telomere 5′ ends

Abstract Telomere DNA ends with a single-stranded 3′ overhang. Long 3′ overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5′ end hyper-res...

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Autores principales: Rikard Runnberg, Saishyam Narayanan, Marita Cohn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ea94b149eb7b4623a8c3eeb2d766981c
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