Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia

Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia

Abstract Chronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. Despite new targeted therapies such as ibrutinib and venetoclax, disease progression and relapse remain an issue. CLL cell interactions with the supportive tissue microenvironment play a...

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Main Authors: Neus Gimenez, Rupal Tripathi, Ariadna Giró, Laia Rosich, Mònica López-Guerra, Irene López-Oreja, Heribert Playa-Albinyana, Fabian Arenas, José Manuel Mas, Patricia Pérez-Galán, Julio Delgado, Elias Campo, Judith Farrés, Dolors Colomer
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/eaa533646552409fbba838dfbdc5b89d
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https://doaj.org/article/eaa533646552409fbba838dfbdc5b89d

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