Structural basis for lamin assembly at the molecular level

Lamins are intermediate filaments and the major component of the nuclear lamina. Here the authors determine the crystal structure of a construct comprising the N-terminal half of human lamin A/C and use their structure and cross-linking and biochemical experiments to discuss lamin assembly.

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Auteurs principaux: Jinsook Ahn, Inseong Jo, So-mi Kang, Seokho Hong, Suhyeon Kim, Soyeon Jeong, Yong-Hak Kim, Bum-Joon Park, Nam-Chul Ha
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/eaabcdf6ad91467b8115d9254282e1c7
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