Structural basis for lamin assembly at the molecular level

Lamins are intermediate filaments and the major component of the nuclear lamina. Here the authors determine the crystal structure of a construct comprising the N-terminal half of human lamin A/C and use their structure and cross-linking and biochemical experiments to discuss lamin assembly.

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Autores principales:	Jinsook Ahn, Inseong Jo, So-mi Kang, Seokho Hong, Suhyeon Kim, Soyeon Jeong, Yong-Hak Kim, Bum-Joon Park, Nam-Chul Ha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eaabcdf6ad91467b8115d9254282e1c7
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spelling	oai:doaj.org-article:eaabcdf6ad91467b8115d9254282e1c72021-12-02T14:38:37ZStructural basis for lamin assembly at the molecular level10.1038/s41467-019-11684-x2041-1723https://doaj.org/article/eaabcdf6ad91467b8115d9254282e1c72019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11684-xhttps://doaj.org/toc/2041-1723Lamins are intermediate filaments and the major component of the nuclear lamina. Here the authors determine the crystal structure of a construct comprising the N-terminal half of human lamin A/C and use their structure and cross-linking and biochemical experiments to discuss lamin assembly.Jinsook AhnInseong JoSo-mi KangSeokho HongSuhyeon KimSoyeon JeongYong-Hak KimBum-Joon ParkNam-Chul HaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinsook Ahn Inseong Jo So-mi Kang Seokho Hong Suhyeon Kim Soyeon Jeong Yong-Hak Kim Bum-Joon Park Nam-Chul Ha Structural basis for lamin assembly at the molecular level
description	Lamins are intermediate filaments and the major component of the nuclear lamina. Here the authors determine the crystal structure of a construct comprising the N-terminal half of human lamin A/C and use their structure and cross-linking and biochemical experiments to discuss lamin assembly.
format	article
author	Jinsook Ahn Inseong Jo So-mi Kang Seokho Hong Suhyeon Kim Soyeon Jeong Yong-Hak Kim Bum-Joon Park Nam-Chul Ha
author_facet	Jinsook Ahn Inseong Jo So-mi Kang Seokho Hong Suhyeon Kim Soyeon Jeong Yong-Hak Kim Bum-Joon Park Nam-Chul Ha
author_sort	Jinsook Ahn
title	Structural basis for lamin assembly at the molecular level
title_short	Structural basis for lamin assembly at the molecular level
title_full	Structural basis for lamin assembly at the molecular level
title_fullStr	Structural basis for lamin assembly at the molecular level
title_full_unstemmed	Structural basis for lamin assembly at the molecular level
title_sort	structural basis for lamin assembly at the molecular level
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eaabcdf6ad91467b8115d9254282e1c7
work_keys_str_mv	AT jinsookahn structuralbasisforlaminassemblyatthemolecularlevel AT inseongjo structuralbasisforlaminassemblyatthemolecularlevel AT somikang structuralbasisforlaminassemblyatthemolecularlevel AT seokhohong structuralbasisforlaminassemblyatthemolecularlevel AT suhyeonkim structuralbasisforlaminassemblyatthemolecularlevel AT soyeonjeong structuralbasisforlaminassemblyatthemolecularlevel AT yonghakkim structuralbasisforlaminassemblyatthemolecularlevel AT bumjoonpark structuralbasisforlaminassemblyatthemolecularlevel AT namchulha structuralbasisforlaminassemblyatthemolecularlevel
_version_	1718390985587687424

Structural basis for lamin assembly at the molecular level

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