KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

Shimoda et al. present evidence that a small functional peptide derived from the KSHV transactivator could be used to target MYC in cancer. The authors find that the peptide attenuates MYC expression, reduces cell proliferation, and selectively kills cancer cells in tissue culture and a xenograft tu...

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Bibliographic Details
Main Authors: Michiko Shimoda, Yuanzhi Lyu, Kang-Hsin Wang, Ashish Kumar, Hiroki Miura, Joshua F. Meckler, Ryan R. Davis, Chanikarn Chantarasrivong, Chie Izumiya, Clifford G. Tepper, Ken-ichi Nakajima, Joseph Tuscano, Gustavo Barisone, Yoshihiro Izumiya
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/eaec3f23d40d4e7a83a5c5ddca22da0a
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