Enrichment of Antigen-Specific Class-Switched B Cells from Individuals Naturally Immunized by Infection with Group A Streptococcus

ABSTRACT The low frequency of circulating antigen-specific memory B cells is a considerable obstacle in the discovery and development of human monoclonal antibodies for therapeutic application. Here, we evaluate two solid-phase isolation methods to enrich the number of antigen-specific B cells from...

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Autores principales: Cheri L. Lamb, Emily Price, Kevin P. Field, Christopher Dayton, Eric R. McIndoo, Eva J. Katahira, Dennis L. Stevens, Sarah E. Hobdey
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
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Acceso en línea:https://doaj.org/article/eb054233c1604f348cbb5d94c5de138a
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