p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors.

p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors.

The KIT-inhibitor imatinib mesylate (IM) has greatly improved the treatment of metastatic gastrointestinal stromal tumors (GIST). IM exhibits strong antiproliferative effects but fails to induce sufficient levels of apoptosis resulting in low pathologic complete remission rates and a high rate of se...

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Bibliographic Details
Main Authors: Joern Henze, Thomas Mühlenberg, Susanne Simon, Florian Grabellus, Brian Rubin, Georg Taeger, Martin Schuler, Juergen Treckmann, Maria Debiec-Rychter, Takahiro Taguchi, Jonathan A Fletcher, Sebastian Bauer
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/eb08851ab2234325acf4d31cce831a44
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https://doaj.org/article/eb08851ab2234325acf4d31cce831a44

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