Proteolysis of the human DNA polymerase delta smallest subunit p12 by μ-calpain in calcium-triggered apoptotic HeLa cells.

Degradation of p12 subunit of human DNA polymerase delta (Pol δ) that results in an interconversion between Pol δ4 and Pol δ3 forms plays a significant role in response to replication stress or genotoxic agents triggered DNA damage. Also, the p12 is readily degraded by human calpain in vitro. Howeve...

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Autores principales: Xiaoting Fan, Qian Zhang, Chao You, Yuanxia Qian, Jing Gao, Peng Liu, Huiqing Chen, Huifang Song, Yan Chen, Keping Chen, Yajing Zhou
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/eb098fcbf5cb411396b420d6ab0f3c29
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