Multiple sclerosis: modulation of toll-like receptor (TLR) expression by interferon-β includes upregulation of TLR7 in plasmacytoid dendritic cells.

Multiple sclerosis: modulation of toll-like receptor (TLR) expression by interferon-β includes upregulation of TLR7 in plasmacytoid dendritic cells.

Interferon-β is an established treatment for patients with multiple sclerosis (MS) but its mechanisms of action are not well understood. Viral infections are a known trigger of MS relapses. Toll-like receptors (TLRs) are key components of the innate immune system, which sense conserved structures of...

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Main Authors: Katja Derkow, Jakob M J Bauer, Michael Hecker, Brigitte K Paap, Madhan Thamilarasan, Dirk Koczan, Eckart Schott, Katrin Deuschle, Judith Bellmann-Strobl, Friedemann Paul, Uwe K Zettl, Klemens Ruprecht, Seija Lehnardt
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/eb1df074a4e941838c7b5bfc2b300752
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https://doaj.org/article/eb1df074a4e941838c7b5bfc2b300752

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