Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway

Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway

The role of type I interferon signalling in the control of myeloid derived suppressor cells (MDSC) activity remains controversial. Here the authors show that downregulation of type I interferon receptor is observed in MDSC from cancer patients and tumor-bearing mice and is required for the activatio...

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Autores principales: Kevin Alicea-Torres, Emilio Sanseviero, Jun Gui, Jinyun Chen, Filippo Veglia, Qiujin Yu, Laxminarasimha Donthireddy, Andrew Kossenkov, Cindy Lin, Shuyu Fu, Charles Mulligan, Brian Nam, Gregory Masters, Fred Denstman, Joseph Bennett, Neil Hockstein, Agnieszka Rynda-Apple, Yulia Nefedova, Serge Y. Fuchs, Dmitry I. Gabrilovich
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/eb47431a860f4ab1b301c7219d4359c8
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spelling oai:doaj.org-article:eb47431a860f4ab1b301c7219d4359c82021-12-02T17:04:51ZImmune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway10.1038/s41467-021-22033-22041-1723https://doaj.org/article/eb47431a860f4ab1b301c7219d4359c82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22033-2https://doaj.org/toc/2041-1723The role of type I interferon signalling in the control of myeloid derived suppressor cells (MDSC) activity remains controversial. Here the authors show that downregulation of type I interferon receptor is observed in MDSC from cancer patients and tumor-bearing mice and is required for the activation of their immune suppressive properties.Kevin Alicea-TorresEmilio SansevieroJun GuiJinyun ChenFilippo VegliaQiujin YuLaxminarasimha DonthireddyAndrew KossenkovCindy LinShuyu FuCharles MulliganBrian NamGregory MastersFred DenstmanJoseph BennettNeil HocksteinAgnieszka Rynda-AppleYulia NefedovaSerge Y. FuchsDmitry I. GabrilovichNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kevin Alicea-Torres
Emilio Sanseviero
Jun Gui
Jinyun Chen
Filippo Veglia
Qiujin Yu
Laxminarasimha Donthireddy
Andrew Kossenkov
Cindy Lin
Shuyu Fu
Charles Mulligan
Brian Nam
Gregory Masters
Fred Denstman
Joseph Bennett
Neil Hockstein
Agnieszka Rynda-Apple
Yulia Nefedova
Serge Y. Fuchs
Dmitry I. Gabrilovich
Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
description The role of type I interferon signalling in the control of myeloid derived suppressor cells (MDSC) activity remains controversial. Here the authors show that downregulation of type I interferon receptor is observed in MDSC from cancer patients and tumor-bearing mice and is required for the activation of their immune suppressive properties.
format article
author Kevin Alicea-Torres
Emilio Sanseviero
Jun Gui
Jinyun Chen
Filippo Veglia
Qiujin Yu
Laxminarasimha Donthireddy
Andrew Kossenkov
Cindy Lin
Shuyu Fu
Charles Mulligan
Brian Nam
Gregory Masters
Fred Denstman
Joseph Bennett
Neil Hockstein
Agnieszka Rynda-Apple
Yulia Nefedova
Serge Y. Fuchs
Dmitry I. Gabrilovich
author_facet Kevin Alicea-Torres
Emilio Sanseviero
Jun Gui
Jinyun Chen
Filippo Veglia
Qiujin Yu
Laxminarasimha Donthireddy
Andrew Kossenkov
Cindy Lin
Shuyu Fu
Charles Mulligan
Brian Nam
Gregory Masters
Fred Denstman
Joseph Bennett
Neil Hockstein
Agnieszka Rynda-Apple
Yulia Nefedova
Serge Y. Fuchs
Dmitry I. Gabrilovich
author_sort Kevin Alicea-Torres
title Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
title_short Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
title_full Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
title_fullStr Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
title_full_unstemmed Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
title_sort immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type i interferon pathway
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/eb47431a860f4ab1b301c7219d4359c8
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