Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the loss of Aire transcriptional activity and inducti...
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Nature Portfolio
2020
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oai:doaj.org-article:eb5aeaaa407a4884ae20cf4e411315b12021-12-02T14:40:42ZDual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance10.1038/s41467-020-15448-w2041-1723https://doaj.org/article/eb5aeaaa407a4884ae20cf4e411315b12020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15448-whttps://doaj.org/toc/2041-1723The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the loss of Aire transcriptional activity and induction of autoimmunity.Yu-San HuohBin WuSehoon ParkDarren YangKushagra BansalEmily GreenwaldWesley P. WongDiane MathisSun HurNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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Science Q Yu-San Huoh Bin Wu Sehoon Park Darren Yang Kushagra Bansal Emily Greenwald Wesley P. Wong Diane Mathis Sun Hur Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance |
description |
The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the loss of Aire transcriptional activity and induction of autoimmunity. |
format |
article |
author |
Yu-San Huoh Bin Wu Sehoon Park Darren Yang Kushagra Bansal Emily Greenwald Wesley P. Wong Diane Mathis Sun Hur |
author_facet |
Yu-San Huoh Bin Wu Sehoon Park Darren Yang Kushagra Bansal Emily Greenwald Wesley P. Wong Diane Mathis Sun Hur |
author_sort |
Yu-San Huoh |
title |
Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance |
title_short |
Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance |
title_full |
Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance |
title_fullStr |
Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance |
title_full_unstemmed |
Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance |
title_sort |
dual functions of aire card multimerization in the transcriptional regulation of t cell tolerance |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/eb5aeaaa407a4884ae20cf4e411315b1 |
work_keys_str_mv |
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