Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the loss of Aire transcriptional activity and inducti...

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Autores principales: Yu-San Huoh, Bin Wu, Sehoon Park, Darren Yang, Kushagra Bansal, Emily Greenwald, Wesley P. Wong, Diane Mathis, Sun Hur
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/eb5aeaaa407a4884ae20cf4e411315b1
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spelling oai:doaj.org-article:eb5aeaaa407a4884ae20cf4e411315b12021-12-02T14:40:42ZDual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance10.1038/s41467-020-15448-w2041-1723https://doaj.org/article/eb5aeaaa407a4884ae20cf4e411315b12020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15448-whttps://doaj.org/toc/2041-1723The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the loss of Aire transcriptional activity and induction of autoimmunity.Yu-San HuohBin WuSehoon ParkDarren YangKushagra BansalEmily GreenwaldWesley P. WongDiane MathisSun HurNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu-San Huoh
Bin Wu
Sehoon Park
Darren Yang
Kushagra Bansal
Emily Greenwald
Wesley P. Wong
Diane Mathis
Sun Hur
Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
description The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the loss of Aire transcriptional activity and induction of autoimmunity.
format article
author Yu-San Huoh
Bin Wu
Sehoon Park
Darren Yang
Kushagra Bansal
Emily Greenwald
Wesley P. Wong
Diane Mathis
Sun Hur
author_facet Yu-San Huoh
Bin Wu
Sehoon Park
Darren Yang
Kushagra Bansal
Emily Greenwald
Wesley P. Wong
Diane Mathis
Sun Hur
author_sort Yu-San Huoh
title Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
title_short Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
title_full Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
title_fullStr Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
title_full_unstemmed Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
title_sort dual functions of aire card multimerization in the transcriptional regulation of t cell tolerance
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/eb5aeaaa407a4884ae20cf4e411315b1
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