TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14

The proteasome-bound ubiquitinase USP14 plays an important role in determining proteasome activity and substrate specificity. Here the authors show that TRIM11, a member of the mammalian tripartite motif family, regulates USP14 and is an important activator of the proteasome.

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Detalles Bibliográficos
Autores principales: Liang Chen, Guixin Zhu, Eleanor M. Johns, Xiaolu Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/eb78696545ab4e1d9c7dde25e577469b
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