TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14

The proteasome-bound ubiquitinase USP14 plays an important role in determining proteasome activity and substrate specificity. Here the authors show that TRIM11, a member of the mammalian tripartite motif family, regulates USP14 and is an important activator of the proteasome.

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Detalles Bibliográficos
Autores principales:	Liang Chen, Guixin Zhu, Eleanor M. Johns, Xiaolu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb78696545ab4e1d9c7dde25e577469b
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spelling	oai:doaj.org-article:eb78696545ab4e1d9c7dde25e577469b2021-12-02T15:33:57ZTRIM11 activates the proteasome and promotes overall protein degradation by regulating USP1410.1038/s41467-018-03499-z2041-1723https://doaj.org/article/eb78696545ab4e1d9c7dde25e577469b2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03499-zhttps://doaj.org/toc/2041-1723The proteasome-bound ubiquitinase USP14 plays an important role in determining proteasome activity and substrate specificity. Here the authors show that TRIM11, a member of the mammalian tripartite motif family, regulates USP14 and is an important activator of the proteasome.Liang ChenGuixin ZhuEleanor M. JohnsXiaolu YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liang Chen Guixin Zhu Eleanor M. Johns Xiaolu Yang TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
description	The proteasome-bound ubiquitinase USP14 plays an important role in determining proteasome activity and substrate specificity. Here the authors show that TRIM11, a member of the mammalian tripartite motif family, regulates USP14 and is an important activator of the proteasome.
format	article
author	Liang Chen Guixin Zhu Eleanor M. Johns Xiaolu Yang
author_facet	Liang Chen Guixin Zhu Eleanor M. Johns Xiaolu Yang
author_sort	Liang Chen
title	TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
title_short	TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
title_full	TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
title_fullStr	TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
title_full_unstemmed	TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
title_sort	trim11 activates the proteasome and promotes overall protein degradation by regulating usp14
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eb78696545ab4e1d9c7dde25e577469b
work_keys_str_mv	AT liangchen trim11activatestheproteasomeandpromotesoverallproteindegradationbyregulatingusp14 AT guixinzhu trim11activatestheproteasomeandpromotesoverallproteindegradationbyregulatingusp14 AT eleanormjohns trim11activatestheproteasomeandpromotesoverallproteindegradationbyregulatingusp14 AT xiaoluyang trim11activatestheproteasomeandpromotesoverallproteindegradationbyregulatingusp14
_version_	1718386999044341760

TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14

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