A switch point in the molecular chaperone Hsp90 responding to client interaction
The heat shock protein 90 (Hsp90) chaperone undergoes large conformational changes during its functional cycle. Here the authors combine in vivo, biochemical, biophysical and computational approaches and provide insights into the allosteric regulation of Hsp90 by identifying and characterizing a swi...
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Nature Portfolio
2018
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oai:doaj.org-article:eb99df2bef0c4d18881cbe90d73b5d152021-12-02T14:40:10ZA switch point in the molecular chaperone Hsp90 responding to client interaction10.1038/s41467-018-03946-x2041-1723https://doaj.org/article/eb99df2bef0c4d18881cbe90d73b5d152018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03946-xhttps://doaj.org/toc/2041-1723The heat shock protein 90 (Hsp90) chaperone undergoes large conformational changes during its functional cycle. Here the authors combine in vivo, biochemical, biophysical and computational approaches and provide insights into the allosteric regulation of Hsp90 by identifying and characterizing a switch point in the Hsp90 middle domain.Daniel Andreas RutzQi LuoLee FreiburgerTobias MadlVille R. I. KailaMichael SattlerJohannes BuchnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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Science Q Daniel Andreas Rutz Qi Luo Lee Freiburger Tobias Madl Ville R. I. Kaila Michael Sattler Johannes Buchner A switch point in the molecular chaperone Hsp90 responding to client interaction |
description |
The heat shock protein 90 (Hsp90) chaperone undergoes large conformational changes during its functional cycle. Here the authors combine in vivo, biochemical, biophysical and computational approaches and provide insights into the allosteric regulation of Hsp90 by identifying and characterizing a switch point in the Hsp90 middle domain. |
format |
article |
author |
Daniel Andreas Rutz Qi Luo Lee Freiburger Tobias Madl Ville R. I. Kaila Michael Sattler Johannes Buchner |
author_facet |
Daniel Andreas Rutz Qi Luo Lee Freiburger Tobias Madl Ville R. I. Kaila Michael Sattler Johannes Buchner |
author_sort |
Daniel Andreas Rutz |
title |
A switch point in the molecular chaperone Hsp90 responding to client interaction |
title_short |
A switch point in the molecular chaperone Hsp90 responding to client interaction |
title_full |
A switch point in the molecular chaperone Hsp90 responding to client interaction |
title_fullStr |
A switch point in the molecular chaperone Hsp90 responding to client interaction |
title_full_unstemmed |
A switch point in the molecular chaperone Hsp90 responding to client interaction |
title_sort |
switch point in the molecular chaperone hsp90 responding to client interaction |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/eb99df2bef0c4d18881cbe90d73b5d15 |
work_keys_str_mv |
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1718390392623202304 |