Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein

Force-dependent transitions can provide insights into the free-energy landscape of proteins. Here, the authors observe the folding and unfolding dynamics of the model protein Csp using magnetic tweezers, from which a free-energy landscape with two energy barriers and a transient intermediate state i...

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Autores principales:	Haiyan Hong, Zilong Guo, Hao Sun, Ping Yu, Huanhuan Su, Xuening Ma, Hu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ebd0c07ae42e46769d108bf1a5dca73b
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spelling	oai:doaj.org-article:ebd0c07ae42e46769d108bf1a5dca73b2021-11-14T12:07:21ZTwo energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein10.1038/s42004-021-00592-12399-3669https://doaj.org/article/ebd0c07ae42e46769d108bf1a5dca73b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00592-1https://doaj.org/toc/2399-3669Force-dependent transitions can provide insights into the free-energy landscape of proteins. Here, the authors observe the folding and unfolding dynamics of the model protein Csp using magnetic tweezers, from which a free-energy landscape with two energy barriers and a transient intermediate state is constructed.Haiyan HongZilong GuoHao SunPing YuHuanhuan SuXuening MaHu ChenNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Haiyan Hong Zilong Guo Hao Sun Ping Yu Huanhuan Su Xuening Ma Hu Chen Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein
description	Force-dependent transitions can provide insights into the free-energy landscape of proteins. Here, the authors observe the folding and unfolding dynamics of the model protein Csp using magnetic tweezers, from which a free-energy landscape with two energy barriers and a transient intermediate state is constructed.
format	article
author	Haiyan Hong Zilong Guo Hao Sun Ping Yu Huanhuan Su Xuening Ma Hu Chen
author_facet	Haiyan Hong Zilong Guo Hao Sun Ping Yu Huanhuan Su Xuening Ma Hu Chen
author_sort	Haiyan Hong
title	Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein
title_short	Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein
title_full	Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein
title_fullStr	Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein
title_full_unstemmed	Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein
title_sort	two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ebd0c07ae42e46769d108bf1a5dca73b
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Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein

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