Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

Ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein that hydrolyzes both ATP and cGAMP. Here the authors present the crystal structures of the extracellular domain of mouse ENPP1 in complex with 3′3′-cGAMP and the reaction intermediate pA(3′,5′)pG and...

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Autores principales:	Kazuki Kato, Hiroshi Nishimasu, Daisuke Oikawa, Seiichi Hirano, Hisato Hirano, Go Kasuya, Ryuichiro Ishitani, Fuminori Tokunaga, Osamu Nureki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ebe2302b87a54099b3035e61f4224abe
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spelling	oai:doaj.org-article:ebe2302b87a54099b3035e61f4224abe2021-12-02T16:50:12ZStructural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 110.1038/s41467-018-06922-72041-1723https://doaj.org/article/ebe2302b87a54099b3035e61f4224abe2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06922-7https://doaj.org/toc/2041-1723Ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein that hydrolyzes both ATP and cGAMP. Here the authors present the crystal structures of the extracellular domain of mouse ENPP1 in complex with 3′3′-cGAMP and the reaction intermediate pA(3′,5′)pG and discuss mechanistic implications.Kazuki KatoHiroshi NishimasuDaisuke OikawaSeiichi HiranoHisato HiranoGo KasuyaRyuichiro IshitaniFuminori TokunagaOsamu NurekiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuki Kato Hiroshi Nishimasu Daisuke Oikawa Seiichi Hirano Hisato Hirano Go Kasuya Ryuichiro Ishitani Fuminori Tokunaga Osamu Nureki Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
description	Ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein that hydrolyzes both ATP and cGAMP. Here the authors present the crystal structures of the extracellular domain of mouse ENPP1 in complex with 3′3′-cGAMP and the reaction intermediate pA(3′,5′)pG and discuss mechanistic implications.
format	article
author	Kazuki Kato Hiroshi Nishimasu Daisuke Oikawa Seiichi Hirano Hisato Hirano Go Kasuya Ryuichiro Ishitani Fuminori Tokunaga Osamu Nureki
author_facet	Kazuki Kato Hiroshi Nishimasu Daisuke Oikawa Seiichi Hirano Hisato Hirano Go Kasuya Ryuichiro Ishitani Fuminori Tokunaga Osamu Nureki
author_sort	Kazuki Kato
title	Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
title_short	Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
title_full	Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
title_fullStr	Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
title_full_unstemmed	Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
title_sort	structural insights into cgamp degradation by ecto-nucleotide pyrophosphatase phosphodiesterase 1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ebe2302b87a54099b3035e61f4224abe
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Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

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