Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements

Identifying gene subsets affecting disease phenotypes from transcriptome data is challenge. Here, the authors develop a method that combines transcriptional data with disease ordinal clinical measurements to discover a sphingolipid metabolism regulator involving in Huntington’s disease progression....

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Main Authors: Leila Pirhaji, Pamela Milani, Simona Dalin, Brook T. Wassie, Denise E. Dunn, Robert J. Fenster, Julian Avila-Pacheco, Paul Greengard, Clary B. Clish, Myriam Heiman, Donald C. Lo, Ernest Fraenkel
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/ec0af8273fb342fcbf9ccadba0111a01
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https://doaj.org/article/ec0af8273fb342fcbf9ccadba0111a01

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