Synthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines.

Synthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines.

The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles from alcohols, malanonitrile and phenols is reported. These novel 2-amino-chromene-3-carbon...

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Autores principales: Hosadurga K Keerthy, Manoj Garg, Chakrabhavi D Mohan, Vikas Madan, Deepika Kanojia, Rangappa Shobith, Shivananju Nanjundaswamy, Daniel J Mason, Andreas Bender, Basappa, Kanchugarakoppal S Rangappa, H Phillip Koeffler
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ec334f3735274b5a85eba3c8c2d4fc77
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https://doaj.org/article/ec334f3735274b5a85eba3c8c2d4fc77

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