The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.

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Detalles Bibliográficos
Autores principales: Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ec5006d7bd3c48149838ce39d9f207f5
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