A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.
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Nature Portfolio
2019
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oai:doaj.org-article:ec5422e66a47466790d6d136a48ebe742021-12-02T17:01:44ZA plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity10.1038/s41467-019-11255-02041-1723https://doaj.org/article/ec5422e66a47466790d6d136a48ebe742019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11255-0https://doaj.org/toc/2041-1723Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.Joshua D. OoiJhih-Hang JiangPeter J. EggenhuizenLing L. ChuaMirjan van TimmerenKhai L. LohKim M. O’SullivanPoh Y. GanYong ZhongKirill TsyganovLani R. ShochetJessica RyanCoen A. StegemanLars FuggerHugh H. ReidJamie RossjohnPeter HeeringaStephen R. HoldsworthAnton Y. PelegA. Richard KitchingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Joshua D. Ooi Jhih-Hang Jiang Peter J. Eggenhuizen Ling L. Chua Mirjan van Timmeren Khai L. Loh Kim M. O’Sullivan Poh Y. Gan Yong Zhong Kirill Tsyganov Lani R. Shochet Jessica Ryan Coen A. Stegeman Lars Fugger Hugh H. Reid Jamie Rossjohn Peter Heeringa Stephen R. Holdsworth Anton Y. Peleg A. Richard Kitching A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity |
| description |
Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice. |
| format |
article |
| author |
Joshua D. Ooi Jhih-Hang Jiang Peter J. Eggenhuizen Ling L. Chua Mirjan van Timmeren Khai L. Loh Kim M. O’Sullivan Poh Y. Gan Yong Zhong Kirill Tsyganov Lani R. Shochet Jessica Ryan Coen A. Stegeman Lars Fugger Hugh H. Reid Jamie Rossjohn Peter Heeringa Stephen R. Holdsworth Anton Y. Peleg A. Richard Kitching |
| author_facet |
Joshua D. Ooi Jhih-Hang Jiang Peter J. Eggenhuizen Ling L. Chua Mirjan van Timmeren Khai L. Loh Kim M. O’Sullivan Poh Y. Gan Yong Zhong Kirill Tsyganov Lani R. Shochet Jessica Ryan Coen A. Stegeman Lars Fugger Hugh H. Reid Jamie Rossjohn Peter Heeringa Stephen R. Holdsworth Anton Y. Peleg A. Richard Kitching |
| author_sort |
Joshua D. Ooi |
| title |
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity |
| title_short |
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity |
| title_full |
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity |
| title_fullStr |
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity |
| title_full_unstemmed |
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity |
| title_sort |
plasmid-encoded peptide from staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/ec5422e66a47466790d6d136a48ebe74 |
| work_keys_str_mv |
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