Rational design of a protein that binds integrin αvβ3 outside the ligand binding site

Integrins are transmembrane proteins that have important roles in cell adhesion and signalling. Here the authors design a therapeutic protein that binds integrin αvβ3, has anti-angiogenic activity, and reduces tumour growth in xenograft models, while being seemingly well tolerated.

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Bibliographic Details
Main Authors: Ravi Chakra Turaga, Lu Yin, Jenny J. Yang, Hsiauwei Lee, Ivaylo Ivanov, Chunli Yan, Hua Yang, Hans E. Grossniklaus, Siming Wang, Cheng Ma, Li Sun, Zhi-Ren Liu
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/ec9a3560640e457f934555c56eaba610
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