Rational design of a protein that binds integrin αvβ3 outside the ligand binding site

Integrins are transmembrane proteins that have important roles in cell adhesion and signalling. Here the authors design a therapeutic protein that binds integrin αvβ3, has anti-angiogenic activity, and reduces tumour growth in xenograft models, while being seemingly well tolerated.

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Autores principales:	Ravi Chakra Turaga, Lu Yin, Jenny J. Yang, Hsiauwei Lee, Ivaylo Ivanov, Chunli Yan, Hua Yang, Hans E. Grossniklaus, Siming Wang, Cheng Ma, Li Sun, Zhi-Ren Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec9a3560640e457f934555c56eaba610
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spelling	oai:doaj.org-article:ec9a3560640e457f934555c56eaba6102021-12-02T17:32:04ZRational design of a protein that binds integrin αvβ3 outside the ligand binding site10.1038/ncomms116752041-1723https://doaj.org/article/ec9a3560640e457f934555c56eaba6102016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11675https://doaj.org/toc/2041-1723Integrins are transmembrane proteins that have important roles in cell adhesion and signalling. Here the authors design a therapeutic protein that binds integrin αvβ3, has anti-angiogenic activity, and reduces tumour growth in xenograft models, while being seemingly well tolerated.Ravi Chakra TuragaLu YinJenny J. YangHsiauwei LeeIvaylo IvanovChunli YanHua YangHans E. GrossniklausSiming WangCheng MaLi SunZhi-Ren LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ravi Chakra Turaga Lu Yin Jenny J. Yang Hsiauwei Lee Ivaylo Ivanov Chunli Yan Hua Yang Hans E. Grossniklaus Siming Wang Cheng Ma Li Sun Zhi-Ren Liu Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
description	Integrins are transmembrane proteins that have important roles in cell adhesion and signalling. Here the authors design a therapeutic protein that binds integrin αvβ3, has anti-angiogenic activity, and reduces tumour growth in xenograft models, while being seemingly well tolerated.
format	article
author	Ravi Chakra Turaga Lu Yin Jenny J. Yang Hsiauwei Lee Ivaylo Ivanov Chunli Yan Hua Yang Hans E. Grossniklaus Siming Wang Cheng Ma Li Sun Zhi-Ren Liu
author_facet	Ravi Chakra Turaga Lu Yin Jenny J. Yang Hsiauwei Lee Ivaylo Ivanov Chunli Yan Hua Yang Hans E. Grossniklaus Siming Wang Cheng Ma Li Sun Zhi-Ren Liu
author_sort	Ravi Chakra Turaga
title	Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
title_short	Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
title_full	Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
title_fullStr	Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
title_full_unstemmed	Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
title_sort	rational design of a protein that binds integrin αvβ3 outside the ligand binding site
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ec9a3560640e457f934555c56eaba610
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Rational design of a protein that binds integrin αvβ3 outside the ligand binding site

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